Cancer cells pop their own nucleus to squeeze through a tight spot

ells perform some moves you definitely shouldn’t try in yoga class. As immune cells hunt down invading microbes, for example, they contort themselves to fit into the narrow gaps between other cells. But they pay a price: Two new studies reveal that these feats of flexibility can burst the membrane that encloses a cell’s nucleus and damage its DNA. The results could ultimately enable researchers to design drugs to prevent cancer cells from migrating to new locations.