The delivery vehicles will initially be piloted by Ford safety engineers with other researchers on board.
Customers will be able to track the delivery process via the Domino's app and will receive text messages on how to retrieve their pizzas once the delivery has arrived.
The text messages will give customers a unique four-digit code to unlock the car's so-called Heatwave Compartment, a container that keeps the food warm in the back of the vehicle.
Screens and speakers on the car's exterior will give users information on how to retrieve their delivery.
A number of start-up delivery services have been experimenting with on-demand delivery of different packages.
Opinion is still divided, however, on whether automation can help solve some major delivery problems, such as how to deliver pizzas to the fifth floor of a college dorm.