The gunfire was first reported before 8 a.m. Friday.
Witnesses said at least one suspect came into the school and opened fire in an art class.
Some students also said the shooter was throwing explosives into a classroom.
As of 9:45 a.m. law enforcement was sweeping the campus for the possibility of explosive devices, a threat they said they were taking “very seriously.”
Some students say they were evacuated down the street to a nearby auto shop as police surrounded the school.
Many parents are now lining up to pick their kids up at the business.
“School shooting in Texas. Early reports not looking good. God bless all!,” President Trump tweeted.
The school is located about 30 miles southeast of Houston.