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Punches were thrown by both men and women over the seats as other passengers stood up to try and get away from the brawl.
The trouble flared on the Ryanair Newcastle to Alicante flight as it was coming in to land.
A video was posted online by Lucy Norris, of Blyth, Northumberland, who was going on holiday with five friends.
The 30-year-old said: "It was just as we were about to land when the woman started kicking off.
"She was shouting, screaming and making a show of herself. She had been rude to a few people on the flight and I think she was mortal drunk.