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American soldiers were reported among the victims after a suicide bomber blew themselves up near a coalition patrol in Syria on Wednesday.
Kurdish news agency ANHA reported that two American soldiers died from their injuries and two more were wounded after the blast in Manbij.
The soldiers were among at least 10 people killed and dozens wounded after the explosion outside a restaurant where the soldiers were eating, the agency said.
ISIS propaganda agency Amaq said the terror group was responsible for the attack.