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A family-of-six, including four children, were killed in a horror blaze as neighbours watching helplessly from the street heard the victims' screams.
The six victims of an apparently accidental kitchen fire appear to be a mother, four children aged three to 11, and a man believed to be a stepson, local media reported.
The children were believed to be two girls and two boys.
Flames erupted on the fifth floor of the apartment building in Harlem in New York and spread rapidly while residents were asleep in the early hours of Wednesday morning.
Firefighters raced to the seven-storey building at about 1.40am local time and spent about two hours battling the inferno before finding the bodies.