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A hundred firefighters are tackling a "serious" blaze near Elephant and Castle railway station in southeast London.
London Fire Brigade (LFB) said three commercial units in railway arches were "completely alight", in addition to six cars and a telephone box.
Video footage shared on social media showed a huge plume of black smoke rising into the sky.
Police at the scene said the smoke was coming from the train station rather than the tube station. Northern Line trains are not stopping there, while Thameslink services are blocked.
LFB is asking people to "avoid the area and close all doors and windows". Fifteen fire engines have been deployed, while the station and nearby buildings have been evacuated.
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Officers at the scene described it as a "major incident" and said road closures were likely to remain for several hours.
"One man is being treated on the scene by London Ambulance Service crews," LFB said.
The incident does not appear to be terror-related, Scotland Yard said. The blaze, which was first reported at 1.43pm, was described by Southwark Council as "serious".